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1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

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Protein Overview: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Synonyms: Acireductone dioxygenase (Fe(2+)-requiring), ARD, Fe-ARD

Gene names: mtnD, MT-ND1, ADI1, GA16655, 12562, LINJ_20_0980, BRAFLDRAFT_119977, IscW_ISCW007295, Phum_PHUM616140, LMJF_20_0970, LBRM_20_5150, CG32068

Database References

UniProtID GeneID
Transparent sea squirt F6W3G8
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197) Q04NC2 4412291
Pseudomonas syringae pv. syringae (strain B728a) Q4ZVB9 3367365
Xanthomonas campestris pv. campestris (strain B100) B0RSM4 6322215
Bacillus anthracis Q6HTY9 1088831
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017