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2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

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Protein Overview: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Synonyms: Picolinate carboxylase

Gene name: Acmsd

Database References

UniProtID GeneID
Rattus norvegicus Q8R5M5 171385
Dictyostelium discoideum Q54LN9 8625659
Mus musculus B9EI97 266645
Sus scrofa P83662
Bos taurus Q0II68 515030
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017