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3-oxo-5-beta-steroid 4-dehydrogenase

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Protein Overview: 3-oxo-5-beta-steroid 4-dehydrogenase

Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.

Synonyms: Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase

Gene name: Akr1d1

Database References

UniProtID GeneID
Rattus norvegicus P31210 192242
Mus musculus Q8VCX1 208665
Homo sapiens A1L4P6 6718
Oryctolagus cuniculus Q9TV64 100008612

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017