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A disintegrin and metalloproteinase with thrombospondin motifs 4

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Protein Overview: A disintegrin and metalloproteinase with thrombospondin motifs 4

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Synonyms: ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1

Gene name: ADAMTS4

Database References

UniProtID GeneID
Bos taurus A6QLR5 286806
Rattus norvegicus Q9ESP6 66015
Mus musculus Q8BNJ2 240913
Homo sapiens O75173 9507
Pongo abelii Q5RFQ8

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017