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A-kinase anchor protein 10, mitochondrial

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Protein Overview: A-kinase anchor protein 10, mitochondrial

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.

Synonyms: AKAP-10, Dual specificity A kinase-anchoring protein 2, D-AKAP-2, Protein kinase A-anchoring protein 10, PRKA10

Gene name: AKAP10

Database References

UniProtID GeneID
Homo sapiens B2R650 11216
Mus musculus O88845 56697
Sus scrofa P57770 397262

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017