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Abhydrolase domain-containing protein 4

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Protein Overview: Abhydrolase domain-containing protein 4

Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.

Synonyms: Alpha/beta-hydrolase 4, Lyso-N-acylphosphatidylethanolamine lipase

Gene name: Abhd4

Database References

UniProtID GeneID
Mus musculus Q8VD66 105501
Bos taurus Q24K17 509896
Homo sapiens Q8TB40 63874

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017