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Activating transcription factor 7-interacting protein 2

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Protein Overview: Activating transcription factor 7-interacting protein 2

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity.

Synonyms: ATF7-interacting protein 2, MBD1-containing chromatin-associated factor 2

Gene name: ATF7IP2

Database References

UniProtID GeneID
Homo sapiens B2RNR2 80063
Mus musculus Q3UL97 75329

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017