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Activin receptor type-1

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Protein Overview: Activin receptor type-1

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.

Synonyms: Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I

Gene name: ACVR1

Database References

UniProtID GeneID
Homo sapiens Q04771 90
Bos taurus Q28041
Rattus norvegicus P80201 79558
Mus musculus P37172 11477
Gallus gallus Q90ZK6 395246

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017