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Activin receptor type-1C

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Protein Overview: Activin receptor type-1C

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Synonyms: Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7

Gene name: Acvr1c

Database References

UniProtID GeneID
Rattus norvegicus P70539 245921
Mus musculus A2AJR4 269275
Homo sapiens Q4ZFZ8 130399

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017