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Acyl-CoA wax alcohol acyltransferase 2

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Protein Overview: Acyl-CoA wax alcohol acyltransferase 2

Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.

Synonyms: Diacylglycerol O-acyltransferase 2-like protein 4, Long-chain-alcohol O-fatty-acyltransferase 2, Wax synthase, mWS

Gene name: Awat2

Database References

UniProtID GeneID
Mus musculus Q6E1M8 245532
Homo sapiens Q6E213 158835

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017