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Acylglycerol kinase, mitochondrial

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Protein Overview: Acylglycerol kinase, mitochondrial

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.

Synonyms: hAGK, Multiple substrate lipid kinase, HsMuLK, MuLK, Multi-substrate lipid kinase

Gene name: AGK

Database References

UniProtID GeneID
Homo sapiens Q53H12 55750
Pongo abelii Q5RED7 100171735
Zebrafish Q1LX48 334270
Mus musculus Q9D087 69923
Xenopus laevis Q7ZYJ3 379163

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017