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ADP-ribosylation factor-like protein 3

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Protein Overview: ADP-ribosylation factor-like protein 3

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit.

Synonyms: Arf-like GTPase 3

Gene name: arl3

Database References

UniProtID GeneID
Zebrafish Q1MTE5 797451
Bos taurus Q2TBW6 540040
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) D6W3W3 856056
Zebra finch B5FYQ0
Pongo abelii Q5RCQ6 100172124
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017