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Aflatoxin B1 aldehyde reductase member 2

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Protein Overview: Aflatoxin B1 aldehyde reductase member 2

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Synonyms: Succinic semialdehyde reductase, SSA reductase

Gene name: Akr7a2

Database References

UniProtID GeneID
Mus musculus A2AMV3 110198
Homo sapiens O43488 8574
Rattus norvegicus Q6P765 171445

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017