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Agouti-signaling protein

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Protein Overview: Agouti-signaling protein

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).

Synonyms: ASP, Agouti switch protein

Gene name: ASIP

Database References

UniProtID GeneID
Dog Q5UK76 492296
Papio anubis A1YL70 100302661
Macaca cyclopis A8CEM1
Celebes black macaque A1YL68
Colobus polykomos Q1XGU5
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017