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Protein Overview: Agrin

Plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Ligand of the MUSK signaling complex that directly binds LRP4 in this complex and induces the phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane.

Gene name: AGRN

Database References

UniProtID GeneID
Gallus gallus P31696 396538
Mus musculus A2ASP9
Discopyge ommata Q90404
Rattus norvegicus P25304 25592
Homo sapiens O00468 375790

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017