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Aldo-keto reductase family 1 member C3 homolog

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Protein Overview: Aldo-keto reductase family 1 member C3 homolog

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Synonyms: 17-beta-hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type 2, Indanol dehydrogenase, Prostaglandin F synthase, PGFS, Testosterone 17-beta-dehydrogenase 5, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Gene name: AKR1C3

Database References

UniProtID GeneID
Pongo abelii Q5R7C9 100174617

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017