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Aldo-keto reductase family 1 member C4

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Protein Overview: Aldo-keto reductase family 1 member C4

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Synonyms: 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Chlordecone reductase, CDR, Dihydrodiol dehydrogenase 4, DD-4, DD4

Gene name: AKR1C4

Database References

UniProtID GeneID
Crab-eating macaque Q95JH5
Macaca fuscata fuscata Q95JH4
Homo sapiens P17516 1109

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017