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Alkaline ceramidase 1

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Protein Overview: Alkaline ceramidase 1

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.

Synonyms: AlkCDase 1, Alkaline CDase 1, maCER1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3

Gene name: Acer1

Database References

UniProtID GeneID
Mus musculus A1L3S2 171168
Homo sapiens Q8TDN7 125981
Zebrafish Q568I2 550266

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017