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Alkylated DNA repair protein alkB homolog 1

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Protein Overview: Alkylated DNA repair protein alkB homolog 1

Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.

Synonyms: Alpha-ketoglutarate-dependent dioxygenase ABH1, DNA lyase ABH1

Gene name: ALKBH1

Database References

UniProtID GeneID
Homo sapiens Q13686 8846
Mus musculus P0CB42 211064

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017