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Alkylated DNA repair protein alkB homolog 8

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Protein Overview: Alkylated DNA repair protein alkB homolog 8

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.

Synonyms: Probable alpha-ketoglutarate-dependent dioxygenase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8

Gene name: ALKBH8

Database References

UniProtID GeneID
Homo sapiens B1Q2M0 91801
Bos taurus A1A4L5 781788
Western clawed frog Q07G10 550051
Mus musculus Q3TUG4 67667
Crab-eating macaque Q95K79

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017