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Alpha-2-macroglobulin

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This section lists products related to this protein that have the highest publication record. We only include products that we can verify to be exact product used in a particular paper.

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Protein Overview: Alpha-2-macroglobulin

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Synonyms: Alpha-2-M

Gene names: A2M, A2mp

Database References

UniProtID GeneID
Bos taurus A8E647 513856
Homo sapiens P01023 2
Pongo abelii Q5R4N8 100173946
Rattus norvegicus P06238 24153
Mus musculus E9QPW0 11287
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017