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Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2

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Protein Overview: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

Synonyms: Alkylated DNA repair protein alkB homolog 2

Gene name: ALKBH2

Database References

UniProtID GeneID
Bos taurus Q0VCG6 511380
Homo sapiens A4PET2 121642
Mus musculus Q6P6J4 231642

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017