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Amiloride-sensitive cation channel 2, neuronal

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Protein Overview: Amiloride-sensitive cation channel 2, neuronal

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Synonyms: Acid-sensing ion channel 1

Gene name: accn2

Database References

UniProtID GeneID
Opsanus tau Q7T1N4
Gallus gallus Q1XA76 426883
Mus musculus Q50K97 11419
Homo sapiens A3KN86 41
Rattus norvegicus O88762 79123

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017