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Amiloride-sensitive cation channel 3

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Protein Overview: Amiloride-sensitive cation channel 3

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Synonyms: Acid-sensing ion channel 3, ASIC3, Dorsal root ASIC, DRASIC

Gene name: Accn3

Database References

UniProtID GeneID
Mus musculus Q6X1Y6 171209
Rattus norvegicus O35240 286920
Homo sapiens B2R9V0 9311

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017