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Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

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Protein Overview: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Synonyms: Multisynthase complex auxiliary component p43

Gene name: AIMP1

Database References

UniProtID GeneID
Chinese hamster O54873 100689238
Mus musculus P31230
Homo sapiens B3KTR2 9255

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017