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Aminopeptidase N

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    average rating # of reviews # of products offered
1. BD BioScience 4.00 1 6,556
2. BioLegend 4.00 1 5,794
3. Life Technologies 3.00 3 9,253

Aminopeptidase N Product Reviews

4 - Excellent (Publishable / Ideal reagent)
Application: FACS
Sample: human peripheral granulocytes (red) vs. B cells (blue)
Buffer: HBSS + 1% BSA
Dilution: 1/100
4 - Excellent (Publishable / Ideal reagent)
Application: FACS
Sample: human peripheral blood cells
Buffer: 2% Human Serum, 0.5 mM EDTA in PBS
Dilution: 1/100
3 - Good (Publishable / Would use again)
Application: FACS
Sample: Human lysed whole blood
Buffer: PBS+1%BSA
Dilution: 1/2
3 - Good (Publishable / Would use again)
Application: FACS
Sample: human lysed whole blood
Buffer: PBS + 1%BSA
Dilution: 1/20

Protein Overview: Aminopeptidase N

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

Synonyms: AP-N, Apn2, Microsomal aminopeptidase

Gene names: APN2, ANPEP, pepN, APN1

Database References

UniProtID GeneID
Tobacco hawkmoth P91885
Bos taurus P79098 404191
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) P45274 950613
Oryctolagus cuniculus P15541 100009167
Gallus gallus D2KKL5 395667
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017