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Amyloid-like protein 1

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Protein Overview: Amyloid-like protein 1

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.

The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

Synonyms: APLP, APLP-1

Gene name: Aplp1

Database References

UniProtID GeneID
Mus musculus Q03157 11803
Homo sapiens O00113 333

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017