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Anaphase-promoting complex subunit 11

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Protein Overview: Anaphase-promoting complex subunit 11

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Synonyms: APC11, Cyclosome subunit 11

Gene names: APC11, ANAPC11

Database References

UniProtID GeneID
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) D6VRX9 851554
Bos taurus Q3ZCF6 616275
Mus musculus Q3UWH1 66156
Dictyostelium discoideum Q54L48 8625855
Schizosaccharomyces pombe (strain 972 / ATCC 24843) P79054 2543187
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017