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Anaphase-promoting complex subunit 2

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Protein Overview: Anaphase-promoting complex subunit 2

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Synonyms: APC2, Cyclosome subunit 2

Gene names: ANAPC2, APC2

Database References

UniProtID GeneID
Homo sapiens Q5VSG1 29882
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) D6VYC2 850818
Caenorhabditis elegans P34513 176139
Mus musculus Q3TCK5 99152
Arabidopsis thaliana Q8GX39 815008
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017