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Anaphase-promoting complex subunit 4

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Protein Overview: Anaphase-promoting complex subunit 4

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Synonyms: Cyclosome subunit 4

Gene names: APC4, Anapc4, cut20

Database References

UniProtID GeneID
Arabidopsis thaliana O65418 828238
Mus musculus Q91W96 52206
Schizosaccharomyces pombe (strain 972 / ATCC 24843) O42839 2542615
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) D6VSA3 851696
Dictyostelium discoideum Q54NI1 8625004
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017