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Angiopoietin-1

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Protein Overview: Angiopoietin-1

Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.

Synonyms: ANG-1

Gene name: Angpt1

Database References

UniProtID GeneID
Rattus norvegicus O35460 89807
Mus musculus O08538 11600
Bos taurus O18920 282140
Dog Q60FC1 403656
Homo sapiens Q15389 284
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017