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Angiopoietin-2

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Protein Overview: Angiopoietin-2

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Synonyms: ANG-2

Gene name: ANGPT2

Database References

UniProtID GeneID
Homo sapiens A0AV38 285
Dog A0A8J8 607616
Rattus norvegicus B1WBY0 89805
Sus scrofa Q9BDY7 396730
Mus musculus O35608 11601
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017