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Angiopoietin-related protein 4

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Protein Overview: Angiopoietin-related protein 4

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Synonyms: Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP

Gene name: Angptl4

Database References

UniProtID GeneID
Rattus norvegicus Q6TMA8 362850
Homo sapiens D6W670 51129
Sus scrofa Q1H5H6 397628
Mus musculus Q78ZJ9 57875
Bos taurus Q2KJ51 509963

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017