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Protein Overview: Ankyrin-1

Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.

Synonyms: ANK-1, Ankyrin-R, Erythrocyte ankyrin

Gene name: ANK1

Database References

UniProtID GeneID
Homo sapiens A6NJ23 286
Mus musculus P70440 11733

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017