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Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

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Protein Overview: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

Synonyms: Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein

Gene name: ASZ1

Database References

UniProtID GeneID
Equus caballus Q2QLA4 100071245
Pongo abelii Q2IBE3 100137026
Callicebus moloch Q2QLB5
Microcebus murinus Q2QL84
Middle-African hedgehog Q00PJ3
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017