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Protein Overview: Apelin

Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

Synonyms: APJ endogenous ligand

Gene name: APLN

Database References

UniProtID GeneID
Homo sapiens Q4VY08 8862
Bos taurus Q9TUI9 282143
Rattus norvegicus Q9R0R3 58812
Mus musculus Q9R0R4 30878

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017