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Apolipoprotein A-V

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Protein Overview: Apolipoprotein A-V

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Synonyms: Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3

Gene name: Apoa5

Database References

UniProtID GeneID
Mus musculus Q8C7G5 66113
Homo sapiens B0YIV9 116519
Rattus norvegicus Q5FVT8 140638

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017