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Apolipoprotein B receptor

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Protein Overview: Apolipoprotein B receptor

Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.

Synonyms: Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor, Apolipoprotein B48 receptor, apoB-48R

Gene name: APOBR

Database References

UniProtID GeneID
Homo sapiens Q0VD81
Mus musculus Q8VBT6 171504

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017