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Apoptosis-enhancing nuclease

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Protein Overview: Apoptosis-enhancing nuclease

Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.

Synonyms: Interferon-stimulated 20 kDa exonuclease-like 1

Gene name: AEN

Database References

UniProtID GeneID
Homo sapiens C9J571 64782
Pongo abelii Q5REE2 100171731
Rattus norvegicus B2GUW6 361594
Mus musculus Q3TKV9 68048

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017