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Apoptosis inhibitor 5

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Protein Overview: Apoptosis inhibitor 5

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Synonyms: API-5

Gene name: API5

Database References

UniProtID GeneID
Gallus gallus Q5ZMW3 423168
Homo sapiens B4DRJ2 8539
Mus musculus O35841 11800
Pongo abelii Q5R644 100173613

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017