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Apoptotic protease-activating factor 1

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Protein Overview: Apoptotic protease-activating factor 1

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

Synonyms: APAF-1

Gene name: Apaf1

Database References

UniProtID GeneID
Rattus norvegicus Q9EPV5 78963
Mus musculus A2RRK8 11783
Zebrafish Q9I9H8 58131
Homo sapiens B2RMX8 317
Dog Q9GL23

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017