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Protein Overview: Aprataxin

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.

Synonyms: Forkhead-associated domain histidine triad-like protein, FHA-HIT

Gene name: APTX

Database References

UniProtID GeneID
Dog P61797 442943
Mus musculus Q7TQC5 66408
Zebrafish P61799 405797
Homo sapiens A8MTN4 54840
Western clawed frog P61801 403092
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017