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Aprataxin and PNK-like factor

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Protein Overview: Aprataxin and PNK-like factor

Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.

Synonyms: Apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, XRCC1-interacting protein 1

Gene names: APLF, CG6171

Database References

UniProtID GeneID
Homo sapiens A8K476 200558
Mus musculus Q8BZL5 72103
Bos taurus A0JNH9 507989
Drosophila melanogaster A8JR14 41872

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017