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Protein Overview: Aquaporin-3

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

Synonyms: AQP-3, Aquaglyceroporin-3

Gene name: AQP3

Database References

UniProtID GeneID
Homo sapiens A8K843 360
Rattus norvegicus A0JPL5 65133
Bos taurus Q08DE6 780866
Mus musculus Q3TU75 11828
Sus scrofa A8IF63 100126235

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017