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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

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Protein Overview: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Synonyms: AGAP-2, Centaurin-gamma-1, Cnt-g1, Phosphatidylinositol 3-kinase enhancer, PIKE

Gene name: Agap2

Database References

UniProtID GeneID
Rattus norvegicus Q8CGU4 65218
Mus musculus Q3UHD9 216439
Homo sapiens A8K9F7 116986

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017