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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

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Protein Overview: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.

Synonyms: Centaurin-delta-2, Cnt-d2

Gene name: ARAP1

Database References

UniProtID GeneID
Homo sapiens A3KLL7 116985
Mus musculus B2RUJ3 69710

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017