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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

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Protein Overview: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA.

Synonyms: Centaurin-delta-3, Cnt-d3

Gene name: ARAP3

Database References

UniProtID GeneID
Homo sapiens D3DQE3 64411
Mus musculus E9QMK7 106952

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017