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Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

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Protein Overview: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). Posseses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.

Synonyms: 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, DEF-1, Differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP

Gene name: ASAP1

Database References

UniProtID GeneID
Homo sapiens B2RNV3 50807
Bos taurus O97902 327705
Rattus norvegicus Q1AAU4 314961
Mus musculus O08612

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017