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Arsenical pump-driving ATPase

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Protein Overview: Arsenical pump-driving ATPase

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.

Synonyms: Arsenical resistance ATPase, Arsenite-translocating ATPase, Arsenite-transporting ATPase

Gene names: arsA, GET3, asna1

Database References

UniProtID GeneID
Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301) O50593
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) P0CM24 3254436
Yarrowia lipolytica (strain CLIB 122 / E 150) Q6C3M9 2912854
Zebrafish B8A663 325704
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) Q4WY07 3512551
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017