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Arsenite methyltransferase

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Protein Overview: Arsenite methyltransferase

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.

Synonyms: Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase

Gene name: As3mt

Database References

UniProtID GeneID
Rattus norvegicus Q8VHT6 140925
Homo sapiens A6NP79 57412
Mus musculus A6H5W4 57344

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017